IHydroxypropyl methylcellulose (HPMC) iyi-ether ye-cellulose esetshenziswa kakhulu eyaziwa ngezici zayo ezinhle kakhulu zokujiya.Isetshenziswa kakhulu ezimbonini ezehlukene, ezihlanganisa ezokwakha, ezemithi, ezokudla nokunakekela umuntu.Kuleli phepha, sigxila emthelela wokujiya we-HPMC futhi sihlole izici ezinomthelela ekuziphatheni kwayo kokuqina.
Indlela yokuqina ye-HPMC yile:
Ukuqina komphumela we-HPMC kubangelwa ukwakheka kwayo kwamangqamuzana ahlukile.I-molecule ye-HPMC iqukethe umgogodla wamaketango e-cellulose anamathelwe i-hydroxypropyl namaqembu e-methyl.Uma i-HPMC ihlakazeka emanzini noma kwezinye izincibilikisi, amaketanga e-cellulose adonsa amanzi futhi akhukhumele, okuholela ekwakhekeni kwesakhiwo senethiwekhi ye-3D.Le nethiwekhi ibamba i-solvent futhi ikhulise i-viscosity noma ukuhlakazeka kwesixazululo.
Izinto ezithinta umphumela wokuqina:
Ukugxila: Ukugxiliswa kwe-HPMC ekwakhekeni kudlala indima ebalulekile emthelela wayo wokujiya.Njengoba ukugxila kuyanda, ama-molecule e-HPMC amaningi ayasebenzisana, okuholela ekuthuthukisweni kwe-viscosity nokuqina.
Isisindo samangqamuzana: Isisindo samangqamuzana e-HPMC sithinta izakhiwo zayo ezishubile.I-HPMC yesisindo se-molecular ephakeme ngokuvamile ibonisa umphumela wokujiya onamandla uma uqhathaniswa namabanga aphansi esisindo samangqamuzana.
Izinga lokushisa: Izinga lokushisa lingathinta ukuziphatha okushubile kwe-HPMC.. Ngokuvamile, ukwandisa izinga lokushisa kunciphisa i-viscosity kanye nemiphumela yokuqina yesisombululo se-HPMC. Nokho, lo mphumela ungahluka kuye ngebanga elithile le-HPMC.
I-pH: I-pH yesixazululo ingase futhi ithinte umthelela wokujiya we-HPMC. Amanye amabanga e-HPMC angase abonise ukujiya okuthuthukisiwe ebangeni le-pH elithile, kuyilapho amanye ezwela kakhulu ekushintsheni kwe-pH.
I-Shear Rate: Izinga lokugunda, noma izinga lapho isixazululo singaphansi kokucindezeleka komshini, singathinta ukuziphatha okushubile kwe-HPMC. Ngamazinga aphansi okugunda, i-HPMC ingase ibonise i-viscosity ephakeme kanye nokuqina okunamandla. amazinga e-shear, njengalapho enyakaza noma efaka isicelo, i-viscosity ingase yehle ngenxa yokuphuka kwe-shear isakhiwo esakhiwe yi-HPMC.
Izicelo ze-HPMC Eqinisiwe:
Umthelela wokujiya we-HPMC uwenza isithasiselo esibalulekile ezinhlelweni eziningi zokusebenza.Ezinye izinhlelo zokusebenza ezijwayelekile zifaka:
Ukwakhiwa: I-HPMC isetshenziswa ezintweni zikasimende ezifana nodaka namathayili okunamathelayo ukuze kuthuthukiswe ukusebenza kwazo, ukugcinwa kwamanzi kanye nokumelana nokucwila.
Ezemithi: I-HPMC iqashwe njenge-thickener ekumisweni komlomo, izixazululo ze-ophthalmic nama-topical gels, ehlinzeka ngokungaguquguquki okufunayo kanye nokulethwa kwezidakamizwa okuthuthukisiwe.
Ukudla Neziphuzo: I-HPMC isetshenziswa emikhiqizweni yokudla eyahlukene njengamasoso, okokugqoka kanye nama-dessert ukuze kuthuthukiswe ukuthungwa, ukuzinza kanye nomuzwa womlomo.
Ukunakekelwa Komuntu Siqu Nezimonyo: I-HPMC ithola izinhlelo zokusebenza emikhiqizweni yokunakekelwa komuntu siqu, okuhlanganisa okhilimu, izinto zokuthambisa kanye nezakhiwe zokunakekelwa kwezinwele, njenge-thickener, stabilizer kanye ne-ejenti yokwakha ifilimu.
IHydroxypropyl methylcellulose (HPMC) ikhombisa izakhiwo ezijiyayo ezibalulekile ngenxa yesakhiwo sayo esiyingqayizivele samangqamuzana nokusebenzisana namanzi.Ukuqonda izici ezithonya umthelela wokujiya we-HPMC, njengokugxilisa ingqondo, isisindo samangqamuzana, izinga lokushisa, i-pH, nezinga le-shear, kubalulekile ekwakhekeni kwemikhiqizo ene-viscosity oyifunayo kanye nokungaguquguquki. izinhlobonhlobo zezimboni, ezihlinzeka ngokusebenza okuthuthukisiwe nezici zomkhiqizo ezithuthukisiwe.
