IHydroxypropyl Methylcellulose (HPMC) iyipolymer eguquguqukayo esetshenziswa kabanzi ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, ukudla, izimonyo, nezokwakha.Izakhiwo zayo ezihlukile ziyenza ibe ikhandidethi elihle kakhulu lezicelo ezinjengokukhishwa kwezidakamizwa okulawulwayo, ama-agent ajiyayo, ukumbozwa kwefilimu, nezinto zokwakha.Kulesi sihloko, sizocubungula indlela yokuhlakaza ye-HPMC, sihlole ukubaluleka kwayo, amasu, kanye nokusetshenziswa kwayo.Ukuqonda indlela yokuqedwa kwe-HPMC kubalulekile ekwenzeni ngcono ukusebenza kwayo kanye nokuzuza imiphumela efiselekayo emikhakheni eyahlukene.
Ukubaluleka kokuqedwa kwe-HPMC
Ukuhlakazwa kwe-HPMC kusho inqubo yokuhlakaza kanye nokuqedwa kwe-polymer endaweni ewuketshezi.Lesi sinyathelo sibalulekile njengoba sinquma izinga lokukhishwa, i-bioavailability, nokusebenza kwemikhiqizo esekelwe ku-HPMC.Ukuziphatha kokuhlakazeka kwe-HPMC kuncike ezintweni ezahlukahlukene, okuhlanganisa ibanga le-HPMC, usayizi wezinhlayiyana, izinga lokushisa, i-pH, kanye nobunjalo bendawo ephakathi nendawo.Ngokutadisha indlela yokuhlakaza, abacwaningi nabakhiqizi bangahlola ukunyibilika, ukukhishwa kwe-kinetics, kanye nokusebenza kukonke kokwakheka kwe-HPMC, okuholela ekuthuthukisweni komkhiqizo okuthuthukisiwe kanye nokwenza kahle.
Amasu okuqedwa kwe-HPMC
Kusetshenziswa amasu amaningana okutadisha ukuziphatha kokuqedwa kwe-HPMC.Izindlela ezisetshenziswa kakhulu zihlanganisa:
a.I-Apparatus I (Isisetshenziswa sikaBhasikidi): Le ndlela ihlanganisa ukubeka isampula ye-HPMC kubhasikidi onenetha, bese icwiliswa endaweni encibilikayo ngenkathi inyakaziswa.Le nqubo ivamise ukusetshenziselwa ukwakheka okukhishwa ngokushesha futhi inikeza ulwazi olubalulekile ngezinga lokuqedwa kanye nephrofayela yokukhishwa ye-HPMC.
b.I-Apparatus II (I-Paddle apparatus): Kule ndlela, isampula ifakwa emkhunjini wokuhlakazeka, futhi i-paddle isetshenziselwa ukunyakazisa okuphakathi.Le nqubo ifanele ukwakhiwa kokukhishwa ngokushesha kanye nokukhishwa okunwetshiwe, okuhlinzeka ngemininingwane ngenani lokuqedwa kanye ne-kinetics yokukhishwa kwe-HPMC.
c.I-Apparatus III (Isisetshenziswa sesilinda esiphindaphindayo): Le nqubo ihlanganisa ukubeka isampula kusilinda esiphindaphindayo, esiya emuva naphambili endaweni yokuhlakazeka.Le ndlela ivamise ukusetshenziselwa ukutadisha ukwakheka kokukhishwa okunwetshiwe okususelwe ku-HPMC futhi inikeza ulwazi ngezinga lokukhishwa nokuziphatha kokusabalalisa izidakamizwa.
d.I-Apparatus IV (I-Flow-through cell cell apparatus): Le ndlela isetshenziswa kakhulukazi ukutadisha ama-patches noma ulwelwesi lwama-transdermal olususelwa ku-HPMC.Isampula ifakwe phakathi kwamakhompathimenti amabili, futhi okulingisayo kuvunyelwe ukuthi kugeleze kusampula, kulingisa ukukhishwa kwesidakamizwa kulwelwesi lonke.
Izicelo zendlela yokuchithwa kwe-HPMC
Indlela yokuqedwa ye-HPMC ithola ukusetshenziswa okubanzi ezimbonini ezahlukahlukene:
a.Imboni yezemithi: I-HPMC isetshenziswa kakhulu njengepolymer ye-matrix yokwakhiwa kokukhishwa kwezidakamizwa okulawulwayo.Indlela yokuhlakaza isiza ukunquma izinga lokukhululwa, ukuziphatha kokusabalalisa izidakamizwa, kanye nendlela yokukhishwa kwamathebulethi asekelwe ku-HPMC, amaphilisi, namaphilisi.Lolu lwazi lubalulekile ekuthuthukiseni ukulethwa kwezidakamizwa kanye nokuqinisekisa imiphumela engaguquki nebikezela yokwelapha.
b.Imboni yokudla: I-HPMC isetshenziswa njenge-ejenti ejiya futhi eqinisayo emikhiqizweni yokudla efana namasoso, okokugqoka kanye neziphuzo.Indlela yokuhlakaza isiza ekuqondeni izici ze-hydration kanye ne-solubility ye-HPMC kumatrices okudla ahlukene, okunikela ekuthuthukisweni kokuthungwa, ukuzinza, kanye nezimfanelo zezinzwa zemikhiqizo yokugcina.
c.Imboni yezimonyo: I-HPMC iqashwe kuzimonyo nemikhiqizo yokunakekelwa komuntu siqu njenge-ejenti eyenza ifilimu, i-emulsion stabilizer, kanye ne-viscosity modifier.Indlela yokuhlakaza isiza ukuhlola ukunyibilika kanye nezakhiwo zefilimu ze-HPMC, iqinisekise ukuthungwa komkhiqizo ofunekayo, ukusabalala, nokuzinza kwempilo yeshelufu.
